Only registered users are allowed to post. To register, please click here

Should you have any problem in posting, registering, or login, please do not hesitate to contact the admin at Marshall.centre(at)gmail(dot)com. In the subject, please use "Help needed for www.helico.com"

Advertisement is not allowed. While we encourage discussion, please try not to promote your website, goods, or unproven treatment here.

This is a non-profit website. We will try our best to help anyone that has question about H. pylori and their treatment. We shall provide the most accurate answer about H. pylori. You can help us by clicking here to keep this forum alive.

Some useful guides
How to post in the forum?
Management of Helicobacter pylori infection—the Maastricht V/Florence Consensus Report
The 5th Chinese Helicobacter treatment consensus
How long should I wait before doing follow up breath/stool test?

If you are confirmed with H. pylori, in your convenient time, please help us with the symptoms survey that you are experiencing.
Symptoms survey
(contributed by frostyfeet)


此网站免费然您阅读。若想分享心得或提问,请先注册
若有困难注册,请联络站长 Marshall.centre(at)gmail(dot)com。标题请用 "Help needed for www.helico.com"
此网站不允许打广告。我们欢迎任何的讨论。但尽量不要推销没医学根据的网站,商品或治疗方案。
此网站是非盈利网站。我们会尽最大能力提供任何有关幽门螺杆菌的讯息。您的捐款可以让我们继续帮助更多的病人。

指南
如何贴文?
欧洲幽门螺杆菌治疗共识 5
第五次全国幽门螺杆菌感染处理共识报告
用药后,多久以后可以再做吹气测试?

Negative at urea breath test

There are several types of tests for H.pylori. The major ones have a their own forum.

Moderators: barjammar, Toni

Abubakar
Posts: 19
Joined: Sun Sep 26, 2021 3:11 pm

Negative at urea breath test

Post by Abubakar »

Hello, hope you all are doing well.
It all have started exactly two years ago at 15/10/2019. Treated for the entire last year considering as GERD. Diagnostic hampered due to covid situation. Came to know inflammation in the stomach by endoscopy 01/01/2021. Took triple therapy which made the symptoms way worse after one month. Started to suffer from many new symptoms. Did another endoscopy & biopsy at August. Endoscopic finding was subepithelial haemorrhage at stomach. Took quadruple therapy and after one month post ABX and 14 days of ppi did a urea breadth test which says negative. Hope it is a true negative by the grace of Almighty.
My DOB is 0.41, cutoff is 4.
I did not take any supplement, probiotic or any known inhibitory food except 1/2 cup green tea, chew little ginger and 3/4 spoon local honey daily.
Is there any chance of false negative by interpreting my DOB?
Want to hear your kind opinion helico expert.
Hope and pray for the healing of each and every person in the world who are going through this disaster.

Helico_expert
Site Admin
Posts: 4466
Joined: Wed Mar 02, 2011 7:20 am

Re: Negative at urea breadth test

Post by Helico_expert »

Hi,
0.41 is pretty low. The lower the number, the more accurate it is.
If you want, you can always repeat the breath test again next month.

it is also common to have the symptoms persist after HP eradication. The symptoms are caused by the damage done by H. pylori, and it takes time for the wound to heal. The more severe the damage, the longer the time it needs to heal.

Abubakar
Posts: 19
Joined: Sun Sep 26, 2021 3:11 pm

Re: Negative at urea breadth test

Post by Abubakar »

Thanks a lot for your quick response.

Can you please give your opinion about the findings of my endoscopy and histopathology-

First endoscopy (01/01/2021)- the mucosa of the body and fundus appeared inflamed.

2nd endoscopy(20/08/2021)- subepithelial haemorrhages are seen at the body and fundus.

Histopathology- the lamina propria contains increased number of mononuclear cells. The gastric glands are unremarkable. No malignancy is seen. No hp is seen.

No hp is seen in biopsy probably as I didn't stop ppi.

Your kind opinion regarding the damage, chance and time for heal will be highly appreciated.

Abubakar
Posts: 19
Joined: Sun Sep 26, 2021 3:11 pm

Re: Negative at urea breadth test

Post by Abubakar »

Waiting for your kind reply.
How severe is my damage according to the findings of endoscopy and histopathology report aforementioned? And according to UBT as I am now free of hp, should I now focus on gut repairing and perform an endoscopy couple of weeks later to check the healing progress or need to do another endoscopy and more elaborate histopathological investigation right now?
Eagerly waiting for your kind opinion.

Helico_expert
Site Admin
Posts: 4466
Joined: Wed Mar 02, 2011 7:20 am

Re: Negative at urea breadth test

Post by Helico_expert »

This is Prof Marshall's response.
This is an interesting question often asked by people who have residual changes after infection with Helicobacter pylori infection. Quite often the appearance of the mucosa is a little red and with the take your spot and this can last the rest of your life. It is a vascular change just like sun damage to the skin on the back of your hands for example.
The histology, after infection with Helicobacter pylori and is likely to continue to contain mononuclear cells of different kinds and these are “memory cells” which are functional residual immune cells capable of proliferating if Helicobacter pylori came back. However they don’t live there dormant and there is always a degree of in “mild chronic inactive gastritis”. The key to Helicobacter pylori is the presence of active neutrophils are indicative of actual Helicobacter in the mucosa. These disappear after affective treatment.
The other are useful thing to do is to have a serology done every 6 or 12 months for a couple of years until it goes to the negative range. It’s going to stay positive for quite a while after treatment but if it gradually declines then that’s excellent evidence that Helicobacter has actually been eradicated. The good news is that Helicobacter reinfection is unlikely, less than 1% per annum in most countries.

Abubakar
Posts: 19
Joined: Sun Sep 26, 2021 3:11 pm

Re: Negative at urea breadth test

Post by Abubakar »

Thanks sir for your valuable opinion.

If those red spots or inflammation in the mucosa are like sun damage and will last for rest of the life then what about the debilitating symptoms like fullness after eating a small meal, stomach burning, indigestion, bloating, burping, constipation and many more. Will these last for the rest of life. How to get rid of all of these? How to heal stomach lining?

Can you please clarify a little more about subepithelial haemorrhages in the stomach. How severe form of gastritis this is?

Thanks once again in advance.

Helico_expert
Site Admin
Posts: 4466
Joined: Wed Mar 02, 2011 7:20 am

Re: Negative at urea breadth test

Post by Helico_expert »

I think you have to find out the reason for the inflammation.
Since you dont have H. pylori, perhaps, the inflammation is from food allergies?
you may want to see a immunologist or dietician to figure this out.

Abubakar
Posts: 19
Joined: Sun Sep 26, 2021 3:11 pm

Re: Negative at urea breadth test

Post by Abubakar »

I have mentioned it in my first post. I have been suffering from h pylori induced gastritis.
Did an endoscopy at 01/01/2021. Finding was inflamed body and fundus. Took triple therapy, which failed to eradicate.
Did another endoscopy at 20th August. Finding was subepithelial haemorrhages in the body and fundus. Took sequential therapy and negative at UBT.
After more than one month, still suffering from all of the symptoms.
That's why I would like to know how severe is the subepithelial haemorrhage and after eradication, how is the chance and how much time it may need to be healed. And any suggestion about the healing supplement would also be highly appreciated.

Helico_expert
Site Admin
Posts: 4466
Joined: Wed Mar 02, 2011 7:20 am

Re: Negative at urea breadth test

Post by Helico_expert »

It's good to know that you have successfully eradicated H. pylori. At least the inflammation will gradually subside and the wound will gradually heal. unfortunately the healing is subjective. Some people feel improvement within weeks; some took months or years.

At the moment, you can only be treated according to your symptoms. So what do you feel when taking PPI? do you feel improvement?

Abubakar
Posts: 19
Joined: Sun Sep 26, 2021 3:11 pm

Re: Negative at urea breadth test

Post by Abubakar »

I am a bit confused about the ppi. Most of the people in the group's used to say they stop ppi after ABX or two weeks later. Even when I stopped ppi for 14 days before UBT, I didn't experience any difference. After UBT I started to take licorice root capsule twice a day for the last one week. But I have been experiencing upset stomach with upper abdominal burning for the last 3/4 days.
After UBT test my doc asked me to take dexlansoprazole 30 twice for months. And I don't know why now even after negative UBT, he told me to consult with a senior doctor. Yesterday I made a visit to another GI specialist. But he didn't prescribe any ppi, rather dompiridone, sucralfate.
So now what should I follow?

Post Reply

Return to “Diagnosis and Testing 检测与实验”