Re: Negative at urea breadth test
Posted: Sat Oct 23, 2021 9:51 am
PPI is to stop acid secretion.
many gastric symptoms are caused by too much acid, or too little mucous protection. So the acid is burning the stomach lining.
UBT can only work in acidic condition. This is because H. pylori doesnt "produce" urease enzyme when the environment is neutral. The urease enzyme making too much ammonia will make the condition too alkaline to survive. The UBT is specifically designed to measure t he urease activity. So if you are taking PPI, there is no acid, then H. pylori is not making ammonia, and you'll get a false negative. That's why you need to stop PPI for 2 weeks before the UBT.
If PPI doesnt help your symptoms, then the doctor will try something else like domperidone or sucralfate.
Domperidone increase the mobility of the peristalsis movement of the stomach. Basically is to let your stomach empty faster. Stop the food being hold up in the stomach and give bloating symptoms.
Sucralfate creates a layer of protection on the stomach lining. The idea is to stop the acid burning the linings and buy time for the wound to heal.
many gastric symptoms are caused by too much acid, or too little mucous protection. So the acid is burning the stomach lining.
UBT can only work in acidic condition. This is because H. pylori doesnt "produce" urease enzyme when the environment is neutral. The urease enzyme making too much ammonia will make the condition too alkaline to survive. The UBT is specifically designed to measure t he urease activity. So if you are taking PPI, there is no acid, then H. pylori is not making ammonia, and you'll get a false negative. That's why you need to stop PPI for 2 weeks before the UBT.
If PPI doesnt help your symptoms, then the doctor will try something else like domperidone or sucralfate.
Domperidone increase the mobility of the peristalsis movement of the stomach. Basically is to let your stomach empty faster. Stop the food being hold up in the stomach and give bloating symptoms.
Sucralfate creates a layer of protection on the stomach lining. The idea is to stop the acid burning the linings and buy time for the wound to heal.