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Talicia (rifabutin, Amox, PPI) said to cause male infertility (can’t be true please)

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downwithhp
Posts: 17
Joined: Sun Jan 12, 2020 2:46 am
Location: United States

Talicia (rifabutin, Amox, PPI) said to cause male infertility (can’t be true please)

Post by downwithhp »

I just found out in a study done on rodents that Talicia which I took to help cure my H pylori infection may cause infertility in male rodents, though after being given 32 times the dose for them. Is this true? I hate to know this treatment I took could do this to me. Maybe I didn’t read the sources right. I need my mind put at ease.

Source: https://www.drugs.com/mtm/talicia.html

Helico_expert
Site Admin
Posts: 3797
Joined: Wed Mar 02, 2011 7:20 am

Re: Talicia (rifabutin, Amox, PPI) said to cause male infertility (can’t be true please)

Post by Helico_expert »

Talicia is fairly new on the market. But the combination is not novel.
PPI and amoxicillin is pretty safe. Rifabutin can be problematic to some people.
Rifabutin is normally reserved for tuberculosis patients. Therefore, the widespread use of this drug may lead to resistance in TB.

my other criticism to this treatment is the use of omeprazole. It's an old drug, which is less effective in some people. They should have used the newer PPI, such as esomepraole or pantoprazole or rabeprazole.

We frequently use rifabutin on our patients. We have about 1 in 100 patients end up in emergency, but nothing serious. It's more of a precaution protocol.

downwithhp
Posts: 17
Joined: Sun Jan 12, 2020 2:46 am
Location: United States

Re: Talicia (rifabutin, Amox, PPI) said to cause male infertility (can’t be true please)

Post by downwithhp »

Helico_expert wrote:
Sun Jun 28, 2020 9:33 am
Talicia is fairly new on the market. But the combination is not novel.
PPI and amoxicillin is pretty safe. Rifabutin can be problematic to some people.
Rifabutin is normally reserved for tuberculosis patients. Therefore, the widespread use of this drug may lead to resistance in TB.

my other criticism to this treatment is the use of omeprazole. It's an old drug, which is less effective in some people. They should have used the newer PPI, such as esomepraole or pantoprazole or rabeprazole.

We frequently use rifabutin on our patients. We have about 1 in 100 patients end up in emergency, but nothing serious. It's more of a precaution protocol.

Thank you. Just to be clear, it’s a low chance it could have effected me in terms of fertility?

Helico_expert
Site Admin
Posts: 3797
Joined: Wed Mar 02, 2011 7:20 am

Re: Talicia (rifabutin, Amox, PPI) said to cause male infertility (can’t be true please)

Post by Helico_expert »

hmm it's a hard question for me.

anyway, I have found this disclosure of rifabutin from Australia
http://secure.healthlinks.net.au/conten ... mycoc11210

In Section 4.6 it says.
Effects on fertilityStudies in rats at oral doses of rifabutin at 160mg/kg/day have shown impairment of spermatogenesis and effects on the gonads without any significant effect on the numbers of live offspring.
it uses 160mg/kg/day.. I think that is a very high dose used.

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