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Split 40 mg omeprazole 1/day to 20mg 2/day midway of treatment?

The cure of Hp usually requires antibiotics. Other things have been tried and have a weaker effect.

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Kimmy123
Posts: 2
Joined: Fri Aug 13, 2021 1:15 pm

Split 40 mg omeprazole 1/day to 20mg 2/day midway of treatment?

Post by Kimmy123 »

Dr prescribed me the following

Omeprazole 40 mg am - wait 30 min for antibiotics
Amoxicillin 1,000 mg 2/day
clarithromycin 500 g 2/day

I’m on day 7 of 14 and finding out 20 mg omelrazole 2/day is best. Anyone think it’ll be bad to switch from 40 mg once a day to 20mg twice a day?

Is 30 min too short between ppi and abx?

Kimmy123
Posts: 2
Joined: Fri Aug 13, 2021 1:15 pm

Re: Split 40 mg omeprazole 1/day to 20mg 2/day midway of treatment?

Post by Kimmy123 »

Like to add the dr originally prescribed me 40 mg twice a day for omeprazole. I am Asian and due to certain gene omeprazole may have high serum concentration due to bioavailability.

When telling the pharmacist this - they changed the Rx with drs orders to 40 mg once a day. ESP since I had headaches my last omeprazole treatment

Helico_expert
Site Admin
Posts: 4600
Joined: Wed Mar 02, 2011 7:20 am

Re: Split 40 mg omeprazole 1/day to 20mg 2/day midway of treatment?

Post by Helico_expert »

twice a day is better than once a day.
I think about half of the Asian has the defective CYP2C19 gene.

perhaps you can switch to rabeprazole, which is not affected by this gene.

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