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欧洲幽门螺杆菌治疗共识 5
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Penicillin allergy

The cure of Hp usually requires antibiotics. Other things have been tried and have a weaker effect.

Moderators: Toni, barjammar, luci2010, Ondek-Expert, kkimura

Plotun
Posts: 50
Joined: Sun Sep 27, 2020 2:48 am

Re: Penicillin allergy

Post by Plotun »

Don't know if doctors here use rifabutin, could they use rifampicin instead rifabutin? Since the duration of my first therapy was 7 days, should it be extended to 10 days this time? Thank You

Plotun
Posts: 50
Joined: Sun Sep 27, 2020 2:48 am

Re: Penicillin allergy

Post by Plotun »

Do you think this clinical trial is reliable?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003218/

I know that you doctors are skeptical, so am I, when alternative clinical trials involving natural remedies comes into consideration, but 66% eradication, although low comparing to standard triple therapies, seems encouraging considering it's natural treatment.

Helico_expert
Site Admin
Posts: 3987
Joined: Wed Mar 02, 2011 7:20 am

Re: Penicillin allergy

Post by Helico_expert »

interesting find.
i am not familiar with it. but it could be true as i know essential oil has strong anti h. pylori effect.

Plotun
Posts: 50
Joined: Sun Sep 27, 2020 2:48 am

Re: Penicillin allergy

Post by Plotun »

I'll try this regime, and if it doesn't work I'll switch to the second line antibiotics therapy. I have an additional question... I've found interesting clinical trial about sulforaphanes (from broccoli sprouts) strong bacteriostatic effect against even helicobacter resistant strains. Daily intake of 100g broccoli sprouts during one month significantly reduced H. Pylori colonization. Do you think, if this first trial (Black seed oil) is true, that sulforaphane addition into the regime could improve eradication/reduction rate. Could it be possible that reducing H. pylori colonization, even though not eradicated, leads to improvement and repairment of gastric mucosa?

Helico_expert
Site Admin
Posts: 3987
Joined: Wed Mar 02, 2011 7:20 am

Re: Penicillin allergy

Post by Helico_expert »

reducing H. pylori is not good enough.
It's like COVID-19. All you need is one case, and soon it will be a cluster.
It's best to eliminate all H. pylori in the stomach.

Plotun
Posts: 50
Joined: Sun Sep 27, 2020 2:48 am

Re: Penicillin allergy

Post by Plotun »

I am aware of that, but I am also aware that I will probably become infected again because of the high prevalence in the area where I live. My symptoms started after a period of prolonged psychological stress. At that point of time, my immunity was heavy compromised, which probably caused H.pylori overgrowth. Therefore, I asked you if the reduction of H.pylori colonization can lead to the improvement of symptoms and the recovery of the gastric mucosa as it was before the clinical manifestation of the disease?

Helico_expert
Site Admin
Posts: 3987
Joined: Wed Mar 02, 2011 7:20 am

Re: Penicillin allergy

Post by Helico_expert »

it's not easy for adults to catch H. pylori again.
H. pylori is sensitive to spices, salt, and heat. So you dont catch H. pylori from street food.
You can catch H. pylori from sharing food with infected person. But again, this can be very rare if everyone you know brushes teeth.
If everyone is aware of oral hygiene, then there is little chance for H. pylori to be found in the mouth and very difficult to spread via sharing food.

Plotun
Posts: 50
Joined: Sun Sep 27, 2020 2:48 am

Re: Penicillin allergy

Post by Plotun »

Ok, thank You for your explanation, but my doctor told me that I'll probably get reinfected at some point. Could You please answer to my question about correlation between reducing/suppressing h.pylori effect of natural remedies, instead of eradication, and repairment of gastric mucosa? Is that even possible, that some natural remedies suppress infection to the point where gastric mucosa heals? I know this isn't permanent solution, but want to buy an extra time until spring (it's winter here right now), when I could find a specialist who can perform biopsy and lab which provides h.pylori resistance test. Don't wanna take unsuccessful therapies over and over again.

Helico_expert
Site Admin
Posts: 3987
Joined: Wed Mar 02, 2011 7:20 am

Re: Penicillin allergy

Post by Helico_expert »

Actually it is your immune system that causes all the problem.
H. pylori has the ability to hide away from your immune cells. So as H. pylori is causing trouble in your stomach, the stomach cells send out signals to gather the immune cells.
The immune cells gathered and cannot see H. pylori. So these immune cells stressed up and start destroying everything, hoping that this mass destruction will get rid of the pathogen.

Therefore, even if there is one H. pylori left, the immune cells will not go away and continue the damage. Some of these damage can be so severe that the cell type is completely replaced by other cell type. and when that happen, the damage is sometimes permanent.

Terra
Posts: 1
Joined: Sat Oct 03, 2020 8:24 pm

Re: Penicillin allergy

Post by Terra »

I am allergic to penicillian plus other antibiotics. It am nterested in learning about treatment options
Thanks

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