Only registered users are allowed to post. To register, please click here

Should you have any problem in posting, registering, or login, please do not hesitate to contact the admin at Marshall.centre(at)gmail(dot)com. In the subject, please use "Help needed for www.helico.com"

Advertisement is not allowed. While we encourage discussion, please try not to promote your website, goods, or unproven treatment here.

This is a non-profit website. We will try our best to help anyone that has question about H. pylori and their treatment. We shall provide the most accurate answer about H. pylori. You can help us by clicking here to keep this forum alive.

Some useful guides
How to post in the forum?
Management of Helicobacter pylori infection—the Maastricht V/Florence Consensus Report
The 5th Chinese Helicobacter treatment consensus
How long should I wait before doing follow up breath/stool test?

If you are confirmed with H. pylori, in your convenient time, please help us with the symptoms survey that you are experiencing.
Symptoms survey
(contributed by frostyfeet)


此网站免费然您阅读。若想分享心得或提问,请先注册
若有困难注册,请联络站长 Marshall.centre(at)gmail(dot)com。标题请用 "Help needed for www.helico.com"
此网站不允许打广告。我们欢迎任何的讨论。但尽量不要推销没医学根据的网站,商品或治疗方案。
此网站是非盈利网站。我们会尽最大能力提供任何有关幽门螺杆菌的讯息。您的捐款可以让我们继续帮助更多的病人。

指南
如何贴文?
欧洲幽门螺杆菌治疗共识 5
第五次全国幽门螺杆菌感染处理共识报告
用药后,多久以后可以再做吹气测试?

Initial treatment failed. Should I be taking this second line treatment okay?

The cure of Hp usually requires antibiotics. Other things have been tried and have a weaker effect.

Moderators: barjammar, Toni, luci2010, Ondek-Expert, kkimura

Post Reply
Wonderboy123
Posts: 7
Joined: Thu Dec 22, 2022 11:32 pm

Initial treatment failed. Should I be taking this second line treatment okay?

Post by Wonderboy123 »

Hi Helico_expert!

I've posted here before about symptoms coming back 2 weeks after my initial treatment in late November, and unfortunately, I've just tested positive again today (with stool test). Looks like we didn't kill off the bacteria completely and it took a while to be visible in the test since I've only been prescribed with PPIs and H2 blockers from Jan - Feb after seeing the GP a couple times for stomach/intestine discomfort.

I went to see my GP today, and was prescribed the same antibiotics (different dosage). So I was wondering if this treatment is okay to take? The reason I am asking is that both here and other online sources recommend switching to a different class of antibiotics (other than Amoxycillin that's hard to become resistant to) after a failed treatment.

My first initial treatment was Amoxycillin 500mg TID, Erythromycin 250mg TID, Omeprazole 20mg BID, Cimetidine 200mg TID.

The second line treatment I was just prescribed was Amoxicillin 250mg + clavulanic acid 125mg QID, Erythromycin 500mg QID, Omeprazole 20mg BID, Cimetidine 200mg QID and Probiotic live lacto-bacillus complex BID.

Thanks in advance!

Helico_expert
Site Admin
Posts: 4600
Joined: Wed Mar 02, 2011 7:20 am

Re: Initial treatment failed. Should I be taking this second line treatment okay?

Post by Helico_expert »

I dont think taking increasing erythromycin dose is going to help.
This is because the gene the antibiotic is targeting has changed. So it doesnt matter how high the dose, it wont work.
unlike metronidazole, it's being pumped out the cell to reduce toxicity.
some mutation can lead to more efficient "pumping".
So increase the dose can compete with the "pumping" and ultimately kill the cell.

So you should try a different class antibiotic, for example levofloxacin or rifabutin. perhaps include bismuth to boost cure rate.

Wonderboy123
Posts: 7
Joined: Thu Dec 22, 2022 11:32 pm

Re: Initial treatment failed. Should I be taking this second line treatment okay?

Post by Wonderboy123 »

I see, thank you so much for responding! I have just booked an appointment to see a specialist on Monday, and hopefully will get another treatment prescribed.

In the mean time, do you think it would be okay to start the medicine (I.e amoxycillin and erythromycin) prescribed by my GP? Last time I took the antibiotics I had an immediate relief on the bloating and pain. If it won't interfere with a new treatment that I maybe starting this Monday (hopefully), then I'd love to take some just to help me through this weekend and to stop the Hpylori from growing.

Helico_expert
Site Admin
Posts: 4600
Joined: Wed Mar 02, 2011 7:20 am

Re: Initial treatment failed. Should I be taking this second line treatment okay?

Post by Helico_expert »

your symptoms were relieved from taking PPI.
you may start the PPI and ignore the antibiotics until a new prescription is given.
take PPI as long as you need to relief the symptoms.
but remember, to get rid of the root of the problem, you need to eradicate H. pylori.

disneywhat
Posts: 5
Joined: Fri Nov 03, 2023 3:21 pm

Re: Initial treatment failed. Should I be taking this second line treatment okay?

Post by disneywhat »

It was the same predicament I was in. Increasing the dosage of erythromycin won't help, in my opinion doodle cricket This is due to a change in the gene that the antibiotic is intended to target. Thus, no matter how large the dosage, it will not be effective.

poorphobic
Posts: 1
Joined: Wed Dec 27, 2023 6:07 pm

Re: Initial treatment failed. Should I be taking this second line treatment okay?

Post by poorphobic »

To lessen toxicity, it is pushed out of the cell, unlike metronidazole. A few mutations may result in "pumping" that is more effective. Raising the dose could therefore cause the cell to eventually die by competing with the "pumpgeometry dash lite." Take PPIs to alleviate your symptoms for as long as necessary. But keep in mind that you must get rid of H. pylori in order to address the underlying issue.

ronaldo99
Posts: 6
Joined: Fri Sep 15, 2023 12:59 pm

Re: Initial treatment failed. Should I be taking this second line treatment okay?

Post by ronaldo99 »

I advise incorporating probiotics into your daily routine,fnf as they can help restore the balance of good bacteria in your gut and alleviate some of the side effects of antibiotic treatment.

Post Reply

Return to “Treatment for Helicobacter 幽门螺杆菌治疗”