Can eradication happen spontaneously?

[Alfred001]

I'm reading a paper entitled Diagnosis of Helicobacter pylori infection in patients with atrophic gastritis: comparison of histology, 13C-urea breath test, and serology and there's this bit in it:

Two of the seven men (29%) who had regression of the corpus
atrophy had spontaneous seroconversion to H. pylori-
negative status during the follow-up period

Note that the authors are comparing blood samples taken 1985-1989 and tissue samples from 1989-1991 to new samples taken 1996-1997 and none of the men had received eradication therapy in the interim.

Now, I don't know whether there are false negatives with the blood tests that could account for this, but has spontaneous eradication been documented?

[Helico_expert]

It is possible to have "spontaneous eradication" of H. pylori.
I believe it can happen when someone has an acute inflammation during the infection.

In your case, can your blood test detect IgM? That is a sign of early infection and I think the "spontaneous eradication" would have happened during early infection.