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2 yrs and half & counting - breath test +ve stool - ve - 3 courses failed

The various unpleasant manifestations of Helicobacter can be described here. Remember however that the great majority of persons with Hp have no symptoms that they are aware of and consider themselves normal.

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Helico_expert
Site Admin
Posts: 4600
Joined: Wed Mar 02, 2011 7:20 am

Re: 2 yrs and half & counting - breath test +ve stool - ve - 3 courses failed

Post by Helico_expert »

I dont like Tetracycline and Amoxicillin combination. The outcome is very conflicting. Of course, your doctor would have more understanding of this combination in your region.

my opinion would be
Rabeprazole 20mg TID
Bismuth 240mg QID
Amoxicillin 1000mg TID
Furazolidone 100mg TID

These are two of those papers that showed PBAT has a poor treatment success rate.
https://www.dovepress.com/efficacy-of-a ... rticle-IDR

https://onlinelibrary.wiley.com/doi/ful ... /apt.12089
Capture.PNG

glglak
Posts: 8
Joined: Sat Feb 16, 2019 12:22 pm

Re: 2 yrs and half & counting - breath test +ve stool - ve - 3 courses failed

Post by glglak »

my region is Sydney, Australia, I am originally from Egypt though, so would you recommend taking a second opinion?
what about the side effects of both treatments, the one you mentioned and the one prescribed? If I decided to go on with doctor recommendation, would it have a chance to increase the bacteria resistence "for tetrcycline"?

Helico_expert
Site Admin
Posts: 4600
Joined: Wed Mar 02, 2011 7:20 am

Re: 2 yrs and half & counting - breath test +ve stool - ve - 3 courses failed

Post by Helico_expert »

H. pylori almost become resistant to tetracycline. But the failure of PBAT is probably the counter interaction of amoxicillin and tetracycline.

I would say Furazolidone has more side effect. But you may not feel it. Not everyone will experience side effects from these antibiotics.

I am bias towards the use of PBAF or PBTF. I am not too keen on PBAT.

glglak
Posts: 8
Joined: Sat Feb 16, 2019 12:22 pm

Re: 2 yrs and half & counting - breath test +ve stool - ve - 3 courses failed

Post by glglak »

Hello,

I mesaage my specialist with all information you sent me and the below is his reply, shall I have a second opinion?

Dear Karim,

Thank you for your email. We have not checked sensitivity to furazolidone as it is not part of our standard sensitivity panel. The choice of amoxycillin + tetracycline was based on the proven sensitivities of your H.pylori organism. So this is not an empiric third line therapy but a regimen based on tested sensitivities. I think that you should have the initially recommended combination and I am happy to send the prescriptions out to you.

Kind Regards,

Stephen Tattersall

Helico_expert
Site Admin
Posts: 4600
Joined: Wed Mar 02, 2011 7:20 am

Re: 2 yrs and half & counting - breath test +ve stool - ve - 3 courses failed

Post by Helico_expert »

Your doctor seems confident with the treatment and you should follow his instruction. Anyway, the recommendation here can always be the backup plan if PBAT failed.

Rashed9
Posts: 12
Joined: Fri Oct 08, 2021 5:56 pm

Re: 2 yrs and half & counting - breath test +ve stool - ve - 3 courses failed

Post by Rashed9 »

Hello . Are you ok? . Did you get rid of it? I did culture and give me same treatment

Hpuk
Posts: 17
Joined: Thu Sep 09, 2021 11:47 pm

Re: 2 yrs and half & counting - breath test +ve stool - ve - 3 courses failed

Post by Hpuk »

Hi Doc,

I'm a 100 percent h pylori can contribute to chronic sinusitis. I've never had health problems in my life till I contracted h plyori 3 years ago. Since then I've had chronic inflammation which went up to my Airways and nostrils. The inflammation remained for a long period and caused polyps to grow in my nose (as chronic inflammation causes polyps). Eventually once I had a bacterial nose block, it would not shift no matter what. I eventually had a CT scan and had to see specialist at the ENT UCLH London, who told me it was due to this inflammation. I ended up having Functional endoscopic sinus surgery to cut the polyps out, and taking steroids to keep it away and reduce inflammation. Its only this year after they discovered the h pylori and antibiotics treatment that the inflammation has subsided. I have also come across a lot of people that have breathing issues due to h pylori.

Helico_expert
Site Admin
Posts: 4600
Joined: Wed Mar 02, 2011 7:20 am

Re: 2 yrs and half & counting - breath test +ve stool - ve - 3 courses failed

Post by Helico_expert »

It is true that H. pylori can sometimes be found in the nasal. Prof Marshall mentioned in a lecture before that sometimes, H. pylori can be found in weird places such as the maxillary sinus. But we have not seen H. pylori causing trouble in the nasal yet.

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