Only registered users are allowed to post. To register, please click here

Should you have any problem in posting, registering, or login, please do not hesitate to contact the admin at Marshall.centre(at)gmail(dot)com. In the subject, please use "Help needed for www.helico.com"

Advertisement is not allowed. While we encourage discussion, please try not to promote your website, goods, or unproven treatment here.

This is a non-profit website. We will try our best to help anyone that has question about H. pylori and their treatment. We shall provide the most accurate answer about H. pylori. You can help us by clicking here to keep this forum alive.

Some useful guides
How to post in the forum?
Management of Helicobacter pylori infection—the Maastricht V/Florence Consensus Report
The 5th Chinese Helicobacter treatment consensus
How long should I wait before doing follow up breath/stool test?



此网站免费然您阅读。若想分享心得或提问,请先注册
若有困难注册,请联络站长 Marshall.centre(at)gmail(dot)com。标题请用 "Help needed for www.helico.com"
此网站不允许打广告。我们欢迎任何的讨论。但尽量不要推销没医学根据的网站,商品或治疗方案。
此网站是非盈利网站。我们会尽最大能力提供任何有关幽门螺杆菌的讯息。您的捐款可以让我们继续帮助更多的病人。

指南
如何贴文?
欧洲幽门螺杆菌治疗共识 5
第五次全国幽门螺杆菌感染处理共识报告
用药后,多久以后可以再做吹气测试?

PPI in Triple Therapy: Questions about timing

The most popular treatments consist of two antibiotics (one of which is usually clarithromycin) plus a strong acid blocker such as omeprazole (PriLosec, Nexium, Somac, Zoton, etc.). Treatment is for 7-10 days. Cure rate is about 85%

Moderators: Toni, barjammar, luci2010, Ondek-Expert, kkimura

Post Reply
eliuri
Posts: 11
Joined: Tue Feb 19, 2019 8:10 am

PPI in Triple Therapy: Questions about timing

Post by eliuri »

Hi:

I'm about to begin triple therapy for H.Pylori: Amoxicillin, Clarithromycin+ PPI (Omeprazole 40 mg)

As prescribed by Gastroenterologist, the PPI is: Omeprazole one tablet 40 mg once daily for 14 days. One hour before meals


When I asked pharmacist to clarify timing of PPI in relation to antibiotics, she said the PPI must be taken very first thing in the morning, even before morning coffee. At least hour before eating anything or taking any medication. Personally, it would be more convenient for me to take it an hour before evening meal..

She was also surprised the PPI wasnt prescribed for twice a day-- but only once daily. So some divergence here from whats on the prescription

Two questions:

1) Can the PPI simply be taken one hour (or more) before evening meal and evening antibiotics, as the prescription implies?

2) Is one 40 mg capsule Omeprazole- once daily- reasonable as part of triple therapy regime? Or might it have been an error and actually that should have been split in two doses?

Thanks

Helico_expert
Site Admin
Posts: 3715
Joined: Wed Mar 02, 2011 7:20 am

Re: PPI in Triple Therapy: Questions about timing

Post by Helico_expert »

answer 1.
it's about consistency. As long as you take it the same time everyday, then the effective dose is maintained in your body and you'll get the same effect.

answer 2.
20 mg twice a day is better. especially some people has higher metabolic rate. the higher dose you take in the morning is probably half gone in the evening. In addition, you might want to try other PPI instead of omeprazole because of that. We prefer rabeprazole. and we give a higher dose, 20mg three times a day.

Post Reply

Return to “Antibiotics and Acid Pump Blockers”