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Another question on false negatives

Blood tests (for antibody) are used to screen for H.pylori. They remain positive for many months after treatment so can only be used as the initial test. Urine antibody is a "pregnanacy style" urine test. Accuracy is slightly less than blood tests. A negative blood test is good evidence that Hp is NOT present. Use it to exclude the diagnosis (but no test is 100% perfect remember).

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Quentin2
Posts: 2
Joined: Mon Oct 19, 2015 3:33 am

Another question on false negatives

Post by Quentin2 »

Hello,

I am suffering from what my doctor believes is a duodenal ulcer. The symptoms started many years ago but disappeared after a couple of weeks, until a year ago when I took ibuprofen for flu symptoms that would not go away. My doctor suspected that the ibuprofen may not have caused the ulcer but merely could have worsened damage done by H. Pylori, so a blood test was done - it came back negative.

Considering that many months have passed now after having stopped the ibuprofen and been on omeprazole and then pantocid and the pain remaining, I am wondering if the two courses of antibiotics I was on (for flu) could have caused a false negative result since I stopped them a day before the test?

Helico_expert
Site Admin
Posts: 3637
Joined: Wed Mar 02, 2011 7:20 am

Re: Another question on false negatives

Post by Helico_expert »

if you took antibiotics, then yes, it's likely to give false negative results. Please follow this guideline to how to use UBT.

http://www.helico.com/PYtest_guide_2013.pdf

Quentin2
Posts: 2
Joined: Mon Oct 19, 2015 3:33 am

Re: Another question on false negatives

Post by Quentin2 »

Thank you for your reply! Just to be sure though, I did not do the breath test, it was the blood test. Does the same apply?

Helico_expert
Site Admin
Posts: 3637
Joined: Wed Mar 02, 2011 7:20 am

Re: Another question on false negatives

Post by Helico_expert »

I am so sorry. My bad. Blood test is very sensitive and unlikely to give false negative result. So, if the blood test is negative, most likely it is true negative. antibiotics or PPI will not affect the blood test result.

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